Chromosomal abnormality in couple with repeated abortion

Abstract

objective: A proportion  of cases with repeated abortion are caused by chromosomal  abnormality  in one or both parents.  Several studies have been done to determine  the role of chromosomal  abnormalities  in couples with repeated abortion.

Subjects and Methods: Cytogenetic study was done for 50 Iraqi couples who presented with repeated abortion at the Medical Center In Mosul Medical College .It was done in a private lab. Celis were studied using lymphocyte culture technique arrested at G- metaphase.

Results: We found that the  percentage  of chromosomal abnormalities  was  (6%). It was not significantly  different from that reported worldwide.  The nature of these abnormalities   were: first case 46, XX,t(5;3X)(q35;q23-q25), second case. 46XY,add(15)(p12)  and the third one 46,XY,del  (16)( q21).

Conclusion:  This study should help physicians working in the region to realize the contribution  of chromosomal abnormalities  as one of the causes of repeated fetal loss. It should also help in setting priorities  of cytogenetic screen individual cases.