Resistin serum levels in psoriasis patients and association with disease severity in Iragi population

Abstract

Psoriasis   is  a  disorder   with   genetic   and   immunologic   background. Psoriasis   is  associate  with  many   metabolic  disorders   like  insulin   resistance. Resistin can involve in development  of psoriasis  by acting as a pro-inflammatory factor   leading  to  an    increased   mRNA  expression  of  many  chemokines   and cytokines   . Our  primary    goals  is to study  the  serum  level  of Resistin   in   psoriasis patients,    and  relation    between   the  Resistin     serum   levels  and  psoriasis    severity. The  study  invelved  60  patients   with  psoriasis   and  40  healthy   controls.   We analyzed   plasma   levels  of Resistin   in psoriasis   patients   and  compared    them  with those  of  healthy   control.   Evaluation    of plasma   levels  of Resistin   was  performed by enzyme immune  sorbent  assay  (ELISA)  . also we study  the relation  between Resistin serum with the severity of psoriasis  that  evaluated  by psoriasis  area  and severity  index (PASI) score.   psoriasis  patients  have considerably  higher  serum levels   of  Resistin    than   heathy   control.    Resistin      serum   levels  were   12.9  +  4.1 ng/ml   , 7.2  +  2.1  ng/ml   in  patients    and   control   group   respectively      .Also  the Resistin   levels were   association    with  severity   of psoriasis   where   serum   levels  of Resistin  were  14.68 + 4.20 ng/ml  and  10.87 + 2.9 ng/ml  in  severe  and  mild  to moderate  cases respectively  .  our results  suggests that the Resistin has important role in development  of psoriasis