Serum Malondialdehyde level in Patients with Hydatid cyst in Mosul City

Abstract

Objectives:  The aim of this study was to investigate the difference in the serum malondialdehyde (MDA) between hydatid cyst  patients and controls.
 Design : case –control study .
 Patients and methods: The study was conducted on patients with CE before the surgical treatment in two general teaching hospitals in Mosul city ( Al-Zahrawy hospital, Al-Salam hospital ) between June 2009 - September 2012. Eighty seven patients with positive Echinococcus granulosus IgG ELISA tests and 103 apparently healthy controls with  negative  E.granulosus IgG ELISA tests .  total   MDA activities of  both patients and controls were determined  by using  thiobarbituric acid Test Assay method ( TBA assay method ). 
Results : The mean age of patients  was  (32.1 ±11.45 ) years and (30.81 ±12.19 ) years for controls . The MDA levels of patients  and controls was statistically significant (p<0.05).  The difference between MDA levels of patients and control group was statistically significant both for females (p<0.05) and males (p<0.05 ) in the patient and control group, The  MDA levels of liver and lung CE was statistically significant 
(p<0.05). while  no correlation was found between age and MDA levels no statistically significant  (p>0.05) both in females and males.  
 Conclusions: In the present study found  the plasma concentration of malondialdehyde (MDA) levels  is higher in  hydatid cyst  patients than controls.