The Immunological Profile of Allergic Rhinitis

Abstract

Allergic rhinitis frequently occurred ,Many types of inflammatory cells and mediators are involved in this disorder. Of particular note is that the pro-inflammatory mediators (e.g. cysteinyl leukotriens, cytokines, and histamine) are involved in nasal and bronchial inflammation, in patients with rhinitis. 
Aim 
  The aim of the study was to define the immunological profile of allergic rhinitis cases in regards to  : Eosinophil count , total IgE levels , specific IgE levels , serum immunoglobulin’s levels , serum complement component( C3,C4 )levels , interleukin 4 and  interleukin 10 levels. Materials and methods: 
  This is a cross sectional study which was carried out on 100 patients with allergic rhinitis) at the Asthma and Allergy Institute in Baghdad, from February 2007 to July 2007, and fifty participants as a control group. Spirometry was performed with the goal of recording as precise as possible of spirometry measures forced expiratory volume in one second (FEV1) and forced vital capacity (FVC).  
Samples of blood were drawn for serological study from all the participants. 
Results and Discussion: 
The age distribution of  Allergic rhinitis showed  the majority  of  cases  occurred between    the age of 5 and 35 years,   but  
The gender distribution showed  female   predominance in allergic rhinitis.                                           
     The mean total serum IgE level in AR was significant higher than its level in the control group (P<0.01).The mean serum concentration of IgG, IgM and C3 complement component were higher in rhinitis patients.