Estimation the relation between Epstein—Barr virus in nasopharyngeal carcinoma with interleukin-10 in Kirkuk city

Abstract

 Background Rickets is a condition associated with bone-deformity due to inadequate mineralization in growing bones. rickets of prematurity is a well-known condition that predisposes to pathological fractures in . The aim of the study was evaluation the frequency of EBV antibodies in nasopharyngeal carcinoma patients and their relation with serum IL-10 level. Patients & Methods: A cross sectional study was carried out from 15th of January 2018 to 15th of June 2018. The number of nasopharyngeal cancer patients under study were 68 patients whose ages were between 7-75 years old. These patients admitted to Kirkuk oncology center, Baghdad oncology center and Al-Sulaimaniya oncology center, while 22 healthy individuals control group, their age ranged between 30-75 years old. All patients and control group were investigated for detection of EBV IgG antibodies and the level IL-10 by using ELISA technique.. The Results: The study showed that the highest rate of EBV-IgG Abs occurred in patients with nasopharyngeal carcinoma (51.74%) comparing with the control group (4.55%). This g. result was highly significant. The highest rate of patients with nasopharyngeal carcinoma was (23.53%) patient within the age group 57-66 years. The least rate of patients with nasopharyngeal carcinoma was (10.29%) patient within the age group 7-16 years. The study showed that (58.82%) of patients enrolled in the study were males and (41.17%) were females. The highest rate (66.18%) of patients with nasopharyngeal carcinoma were in the stage of metastasis comparing with (33.82%) of patients without metastasis. The highest rate (71.43%) of EBV infection was found in patients with metastasis. The highest mean of IL-
10 (42.31 pgiml) in patients with nasopharyngeal carcinoma who were infected with EBV, followed by those without EBV infection (37.38 pg/m1), while the control group recorded a mean of (2.50 pg/ml), the relation was highly significant (P = 0.00001). Conclusions: study was concluded that there is a highly significant relation between EBV 
and 1L- 10 among patients nasopharyngeal carcinoma.