Serum Level of Preptin Hormone in Children with Type-1 Diabetes Mellitus

Abstract

Background Preptin is a hormone which is calm of 34-amino acids (MS 3948 kDa). It is a peptide that is secreted along with insulin and amylin from the fl-cells of the pancreas. The aim of the present study was to estimate the serum level of preptin hormone in children with type I diabetes mellitus getting an insulin therapy. 
Patients & Methods: In this study, a sample which consisted of 35 children with type I diabetes mellitus receiving a treatment of insulin therapy (ages range from 7 to 12 years) and 30 apparently healthy children of a comparable age. Preptin hormone was measured via ELISA, while the blood glucose was measured by UV-VIS spectrophotometer. The Results: The result of this study reveals that preptin has a mean serum level of 82.79 + 4.3 ng/ml in children with type-I diabetes mellitus, while its serum level in control group was 138.62 ± 6.1 ng/ml. It is also found in this study that the BMI of the studied group lower than the control children. In conclusion, preptin is found to be significantly lower in children with type-I diabetes mellitus in comparison with the control group. Conclusions: In conclusion, the preptin hormone was found lower in children with type-I diabetes mellitus in comparison with non-diabetic children.