Determination of testosterone level in male patients with insulin resistance at Tikrit city

Abstract

ABSTRACT: Background The low levels of testosterone in men have been shown to be associated with type 2 diabetes, visceral adiposity, dyslipid-aemia and metabolic syndrome. The effect of 4 testosterone treatment had been investigated on insulin resistance and glycemic control in men with type 2 diabetes.Aim : To investigate the relationship between insulin sensitivity and testosterone level. Patients & Methods: This was study include 50 diabetic men treated with age (35- 7.= 65years) with type 2 diabetes attended the out-patients clinic/medicine department in Tikrit Teaching Hospital. This study was carried out from November 2012 up to May 2013. Patients history were taken and their concomitant medications, Physical examination and laboratory investigations done before and after testosterone therapy (injectionioral root) for 44 3 months.

Results :The present study revealed that (68%) were obese and increase waist circumference t- in (96%)with significant increase in Glycated hemoglobin in obese groups. hyperinsulinaemia in (28%) and low testosterone level in (60%). Although, hyper cholesterolemia present more than half but not reach to statistical significant level while . significant increase triglyceride level especially in obese patients .About lipoprotein types showed significant reduction in HM, and increase In LDL but not for VLDL. Regarding electrolytes level, we found that (Ca),(P) levels appeared within the normal levels, while j. other electrolytes (Mg,K,Na), the majority of cases are within the normal levels. Patients 74 were treated with i.m. testosterone 200 mg every 3 weeks or oral root for 3 months. Follow I up study with testosterone therapy, the primary outcomes was significant decrease in glycated hemoglobin with no corresponding reduction in insulin level, while significant increase in testosterone level.However, a significant reduction in visceral adiposity as fl assessed by waist circumference, with significant reduction in weight and BM1 . With s.: respect to total cholesterol, was reduced in(76%),after testosterone therapy, but statistical analysis not significant. According to triglyceride level, after testosterone therapy,there was significant reduction as compare with it before treatment.There was no significant change in HDL and LDL, while significant reduction present in VLDL.With respect to electrolytes -4 there was significant change except Ca.