Diagnostic and Prognostic role of CAl25 with patients of ovarian cancer

Abstract

To evaluate the diagnostic and prognostic significant of CA 125 test , within a fallow up of three months , and its role for monitoring response to treatment by chemotherapy . To evaluate serum C-reactive protein (CRP) as a prognostic variable in patients with ovarian cancer . This study was conducted in Mosul . Iraq from January 2007 through July 2009 . A sample of 44 consecutive women aged from (35-55 years) and suffering from ovarian cancer with control group of 45 women were included in this study . A pre-tested questionnaire was employed to obtain information on family history to this disease , laporatomy treatment if present , asking for benign disease of the uterus , liver and gastro intestinal tract and benign tumors of ovaries & uterus if present specially for control group . Physical examination by C.T. scans and ultra sounds were then done . Blood samples were collected for 89 women and measurement of CAl25 and CRP were performed . Serum from 44 patients participant were analyzed for CAl25 and CRP before and after treatment with chemotherapy and laporatomy if present at three months interval for fallow up mean ± SD for these patients before chemotherapy course was 78.42 ± 14.6 U/ml for CAl25 in which CRP concentration for 37 patients of this group at the same period of time was 96 mg/dl 84.1% (group 1) and the remainder 7 patients was 48 mg/di 15.9 % (group 2) . There was a significant differences for CAl25 value in patients before therapy and according to period of therapy at P<0.01 . CRP concentration was 96 mg/dl still high after one month of chemotherapy , its value was decrease in the second and third month of chemotherapy . Preoperative determination of CA 125 may play a good role the prognosis of post operative chemotherapy . It may be useful to included this test in the diagnosis of ovarian cancer with the help of physical examination in future .