Crinone versus duphaston in the prevention and treatment of threatened preterm labour

Abstract

To compare the efficacy of oral dydrogesterone with that of vaginal micronized progesterone gel for prevention &treatment of threatened preterm labour. A total of 100 pregnant lady were divided into two groups, one group had received oral dydrogesterone and the other group had received vaginal micronized progesterone gel, selection criteria included: pregnant ladies with singleton viable pregnancy between 24-36 completed weeks of gestation with intact membranes. Demographic profile with pregnancy length &neonatal outcome.Vaginal micronized progesterone gel was more effective than oral dydrogesterone regarding prolongation of pregnancy and neonatal outcome. 9(18%) versus 14(28%), 5(10%) vrsus 8(16%) respectively. Conclusion:-Vaginal micronized progesterone gel deems promising drug for prevention and treatment of threatened preterm labour, although, further studies are needed to confirm our study fmdings.