ACTIVITY OF PHOSPHO EXTRACELLULAR SIGNAL-REGULATED KINASES p(ERKl and ERK2) lN SERUM OF INFERTILIZED (STERILE)WOMEN lN SALAHDEEN GOVERNORATE/ IRAQ

Abstract

Background: Infertitity is one of the most common female disease and it is defined as the inability of getting pregnant after trying for more than one year, without use of birth control means and while having normal sexual intercourse.
Objective: To know the activity of phosphoextracellular  signal regulated kinase p(ERK1 and 2) in infertile women in serum and its correlation with age.
Patients and Methods: This study was carried out in Tikrit Teaching Hospital in salahdeen Governorate - Iraq, from December 2013 to February 2014. ln this study, forty-six women (25 infertile married women and2l apparently healthy women considered as control); their ages range from 16 t0 39 years, were collected to investigate their p(ERK1 and 2) activity in serum by using enzyme linked immunosorbent  assay (ELISA) technique .
Results: Serum p(ERKI and 2) activity was signilicantly decreased in infertile women, mainly in women more than 25 years of age.
Conclusion:  Serum p(ERKl and 2) activity were significantly less among infertile women than the control group. Women with age more than 25 years had less activity compared to infertile women less than 25 years of age. A significant statistical negative correlation was seen between serum p(ERKl and 2) activity and the age.