Evaluating of 8-Hydroxy-Deoxyguanosine lnterleukin-6, lnterleukin-7 In Acute Kidney lnjury lraqi Males

Abstract

Background: Acute kidney injury (previously known as acute renal failure) is a sudden loss in kidney function. There are a number of triggers, including blood and fluid loss from accident, dehydration, burns, or surgery, side effects from drugs, cardiovascular  disease, infection, liver failure or severe allergic reaction.
Objective: The aim of the present study was to assess five important factors in patients with AKI (the amount of 8-OHDG, il-6r IL7, Blood Pressure, and Pulses). These factors were surveyed in AI(I patients to compare with healthy controls and find out the correlation between AKI and serum 8- OHDG,ll-6rlJ.7, Blood Pressure, and Pulses levels
Materials & Methods: The study was conducted prospectively between the dates June 2012 and April 2013. Population of the study consists of 41 patients diagnosed with acute kidney injury (AKI) and a control group of 41 healthy people. 8-OHDG, interleukin-6, interleukin-7 and blood pressure levels were evaluated in all subjects.
Results: Serum levels of inflammation  markers, IL6 and IL7 were signilicantly  increased in
AKI group versus control group. The percent of DNA damage of peripheral btood mononuclear cells was higher in AKI patients (23.24+10.84 ng/mt) compared to healthy controls (830$.S6 nglml) (p<0.001). Pearson correlation analysis showed a significant positive correlation of DNA damage with IL6 and IL7, but not with Sys.BP, Dia.BP, pulses and age.
Conclusion: the results of the present study suggest that 8-OIfdG tevel in Acute kidney injury may be a useful marker of DNA damage also blood &OHdG had significantly  positive correlation with IL6 and II-7. Oddative stress may serve as a risk factor for the presence of Acute kidney injury in Iraqi men.