High sensitivity C-reactive protein in preeclamptic (PE) women

Abstract

Preeclampsia is an exacerbation of generalized inflammatory  response, physiologically  present in the third trimester of pregnancy.
Aim: To evaluate TM-cr and hs-CRP measurement in the context of preeclampsia.
Patients and methods:
A case control study design was performed. The study included (25) non pregnant women (groupl), (25) normotensive  pregrrant women (goup 2) and (25) pregrrant women complicated  by preeclampsia of singleton gestation in the third trimester (group 3) who were attending AL- Batool teaching hospital and AL- Hadba antenatal clinic in Mosul city during a period of 6- months from 1 st November 2012 to lst May 2013. For urinary protein determination  of proteinuria by reagent strip was done.
Serum hs-CRP and TNF-a levels were determined using enryme linked immunosorbent  method. Results:
The results obtained revealed a highly significant increase in circulating hs-CRP levels in the last trimester of pregnancy compared to non pregnant women with p<0.0001, and a sigrrificant increase in serum TNF-cr and hs-CRP levels were also found among preeclamptic women with p < 0.001 compared to normotensive pregrant women.
While, TNF-cr, showed a significant positive correlation with hs-CRP in preeclamptic  women (r- 0.47, p<0.001).
Conclusion:
Data of the present study show that both hs-CRP and pro -inflammatory cytokines are present in higher concentrations in women with preeclampsia which highlight the importance of measuring hs-CRP, TNF-δ in preeclamptic women which may contribute to the pathophysiologl of this pregnancy disorders.