Assessment of Some Biochemical Parameters to Evaluate the Endothelial Function ir Patients with Sickle Cell Disease

Abstract

Sickle cell disease (SCD) is hematological disease that affect the endothelial
function, the hemoglobinopathy of this disease triggers erythrocyte polymerization. The sickling process leads to vascular occlusion, tissue hypoxia and subsequent reperfusion injury, thus inducing inflammation and ndothelial injury (EI). Thirty sickle diseas patients (15 females and 15 males) with a mean age of (27.0 ± 8.9) and 30 healthy cont ols (18 females and 12 males) with a mean age of (29.7 F 9.1) participated in the study Assessment of endothelial function done by studying biochemical parameters which includes; serum nitric oxide, serum endothelin-1, vascular cell
adhesion molecule-1, and serum nterlokin-6 The results showed that all the biochemical parameters that measured in this study were not significantly diffe rent between the patients with sickle cell disease and control
subjects, except the serum level of nitric oxide level in patients with sickle cell disease (2.90 ± 2.57) was significantly lower ( = 0.02) than that of controls (8.49 ± 9.36). From all these find ngs, we can conclude that SCD patients have some degree of impairment of endothelial functin.