Physiological study for some blood parameters in patients with major B-Thalassemia in Sulaymaniyah, Kurdistan, Iraq.

Abstract

B-thalassemia is an inherited hemolytic disorder caused by partial or complete deficiency of a or B- globin chain synthesis. The disease leads to serious health problems unless treated by regular blood transfusion and iron chelating therapy. The present study carried out on ( 90) males and females their age from (12-30 ) years with ß - thalassemia during spring of 2014, there were (70 ) of them infected with ฿ - thalassemia ( major) , who registered at Center of thalassemia and inherited blood disorders, Shaheed Hemin teaching hospital, Sulaymaniyah, Kurdistan, Iraq, while ( 20) healthy used as a control group. The results present study showed that a significant decrease (p < 0.05 ) in number of red blood cells and the concentration of heamoglobin and packed cell volume ( PCV ) of infected patients with ß- thalassemia major compared with control group, while the results showed increase in the total number of white blood cells in infected objectives with the disease compared with the control group and this increase was a significant increase (P < 0.05 ), as the current research patients had blood group (O) were the most susceptible to the infection with B-thalassemia compared with the other blood groups, as the infected objectives who carry the factor rhesus positive (Rh+ ) were (% 76) higher than the patients with rhesus factor negative (Rh- ) (24 %).