Study the physiological and histological changes in mice liver that infected with Candida albicans and the role of camel's milk to treatment

Abstract

The present study used 16 albino mice Mus musculus that divide randomly to four
groups (each group consist 4 mice), the first group was control group administrated only normal diet and water, the second group injected intraperitoneally LD50 (5x105 CFU/ml), the third group injected with infectious dose of Candida albicans (8x104 CFU/ ml), the fourth group injected with infectious dose and treated with camel milk with dose (1 ml). The GOT and GPT levels were
increased and showed high significant changes (P < 0.01) in groups that administrated with LD50% and infected dose compared with control group but its back to normal when treated with camel milk. The microscopic examination showed many changes in liver of groups that injected with lethal and infectious dose from C. albicans including degeneration, fibrosis, infiltration of lymphocytes, congestion and thickening wall of central veins. The liver tissue in group that injected with infectious dose and treated with camel milk showed enhancement in the arrangement of hepatocytes and the liver tissues return to the normal form and structure. It was concluded from this study that camel milk has amply good effect on liver enzymes and tissue.