Oxidative Stress in Patients with Multiple Sclerosis on Interferon Therapy

Abstract

Controlled comparative clinical trial, conducted on the department of neurology, Ibin Sina teaching hospital, Mosul -Iraq, to evaluate the oxidative stress status in patient with multiple sclerosis. Thirty female patients diagnosed as multiple sclerosis enrolled in the study, thirty healthy individuals matched for age with patients group, kept as a control. Malondialdehyde (MDA) were measured in both groups as indicator of oxidative stress. The MDA level was higher in patients with multiple sclerosis than the
control group. The present study demonstrated that patients with multiple sclerosis have exaggerated oxidative stress, and indicate that treatment with antioxidants might theoretically prevent propagation of tissue damage and improve both survival and neurological outcome of the disease.