Oxidative Stress and Some Cellular Blood Vacables in Morphine Addicted Female Rats

Abstract

Morphine belongs to a group of medicines called analgesics. It is an opioid analgesic that acts by blocking pain and it has high addiction property. Therefore, morphine is commonly abused narcotic analgesic in the world besides to heroin which is synthesized as morphine derivative and came into use. This study investigated the role of morphine addiction on lipid peroxidation and alteration of blood cells in female rats. The experimental rats divided to two groups;
Control group and Morphine treated group (The rats were treated with i.v. injection
(150mg/kg) morphine sulfate twice weekly for two weeks). The Blood samples were taken for assessing blood cell variables and the sera were used for Malondialdehyde (MDA) evaluation. The data revealed a significant (P<O.OI) elevation of MDA in morphine treated rats. Slight anemia were appeared in morphine treated rats, as the level of Hb decreased significantly (P<0.05) and the Mean Corpuscle Volume (MCV) and Red cell Distribution Width (RDW) again slightly decreased, but non-significantly. There were significant declining of the level of Mean platelet volume (MP V) and plat&tcrit (PCT) in morphine treated animals. This finding explains the adverse effects of morphine addiction on oxidation level in the body besides to its action on the structural and numerical variables of blood cells in female rats.