The Efficacy of Platelet-Rich Plasma in Rheumatological Disorders

Abstract

The aim of this study is to evaluate the benefit of intra articular and intra lesional platelet-rich plasma (PRP) injections in a group of  patients  clinically  diagnosed  with  primary  and  secondary osteoarthritis, athletic trauma and various tendinopathy and to determine  the  response  of  patients  in  addition  to  number  of frequency of injections and time needed to follow up these patients. 
This study was carried out among 48 patients (16 males and 32 females) from Salah Eldin city whose ages distributed between 22-
72 years with mean (47 years) attended to rehabilitation hospital in Tikrit. All were reviewed with history, through examination and investigation. Sample of venous blood (8ml) was aspirated and 
filled  in  a  special  tube  containing  anticoagulant  citrate  with addition  of  calcium  chloride  to  concentrate  platelets  then centrifuged for 15 minutes in a dedicated centrifuge speed of 2500 cycles/minute  to  separate  platelet-rich  plasma  and  gelatinous material from concentrated RBCs. The result showed significant between  severity  of  pathology  and  pain  relief,  it  was  shown relative response of mild to  moderate osteoarthritis of knees, chondrocalcinosis,  tendon  sprain  and  partial  meniscus  tear. Also,this study didn’t registered any post-injection infection or allergic reaction and discomfort subsided after three days.