Association Risk Factors of Coronary Artery Disease with Total Iron Binding and Serum Ferritin Capacity in Men at Tikrit City

Abstract

Background Many international studies have discussed the important of serum ferritin and other  iron status as a risk marker in coronary artery disease(CAD).  Aim: is to assess the effect of serum iron, total iron binding capacity(TIBC)  , and serum ferritin  on coronary artery disease (CAD) and their relationship with other risk factors.
Patients and Methods a  case control study carried out from November 2016 and for 3 months duration enrolled on 96  male  with age over 35 years,48 healthy men without (CAD)  as control  and other 48patients attending in Tikrit teaching  hospital suffering of (CAD).All participants were assessed physically examination like blood pressers measurement, Wight and height. Then, the blood collected after 14 hours for measurement lipid profile , serum ferritin, serum iron, and total iron binding capacity (TIBC).Data analyses  done include, t-test , chi-square test, and one-way ANOVA.
Results revealed that  significant difference was found among the controls and CAD patients regarding the occurrence of  BMI, blood presser(Systolic and diastolic) and fasting blood sugar were high significant in CAD patients as compared to normal healthy controls. However, significant differences was not observed in age groups. Regarding to Lipid profile(TG ,LDL-C and  HDL-C  ) . LDL-C and  TG were high significant in CAD patients as compared to normal participants controls, while HDL-C was low significant  in CAD patients as compared to normal healthy controls. About  iron state ,it is evident that significant with Hemoglobin and TIBC  at level p<0.05. No significant  differences of serum ferritin  were observed  between  CAD patients and controls, while become significant when assocated with other risk factors like obesity, hypertension, diabetes mellitus, and low LDL-C, but not with other parameters such as high TG , low HDL-C,high LDL-C, low TIBC,smoking and low exercise. Conclusion: Study concluded that serum ferritin might serve as risk factor for coronary artery disease when associated with other risk factors like obesity, hypertension, diabetes mellitus,and  hyperlipidemia.