Evaluation of Thyroid Autoimmunity's in Women with Polycystic Ovary Syndrome

Abstract

Background Polycystic Ovary Syndrome - PCOS- is the most common endocrine disease that affects women of reproductive age. The Aim is to assess the levels of thyroid antibodies in women with PCOS in Iraq, and to learning the link between PCOS and thyroid hormones. 
Patients & Methods: Two study groups have been investigated; the first group consists of one hundred and five infertile women with PCOS. The second group is healthy  control  which  consists  of  forty  six  healthy  fertile  women.  Hormonal analysis was performed by using a ready kit in accordance with the manufacturer's instruction (Biomerieux SA Etoile-France) and minividas full automated system (Triiodothyronine) .Thyroxine is performed by a one-step enzyme immunoassay competition  method with a final fluorescent detection (ELIFA) (Enzymelinked immunoflourecent assay) and minividas full automated system (Biomerieux SA Etoile- France). Thyroid  stimulation  hormones  ,  anti  -thyroid  peroxidase autoantibodies ,anti-TPO and anti -thyroglobulin antibodies Tg is performed by means  of  immunoassay  sandwich  with  a  final  fluorescent  detection  (ELIFA) method with the use of a ready kit in accordance to the manufacturer's instruction (Biomerieux) and MiniVidas Full automated system (Biomerieux).
The Results: It was found a highly significant difference (p< 0.01) between the thyroid stimulation hormone means (7.03± 13.45) µIU/ml of the infertile women with  a  mean  of  (3.51±4.43)  µIU/ml  of  the  control  group,  while  the  mean  of Triiodothyronine  and  Thyroxine  was  found  a  slightly  significant  difference (0.05>p>0.1),). A positive result was found for thyroid peroxidase antibody (TPO- Abs)in infertile women (19.95 1± 39.53) IU/ml was higher than that of the control (4.82±4.7   ) IU/ml; anti-Tg autoantibodies in infertile women were (31.31±65.86) IU/ml  compared  to  control  (11.75±27.30)  IU/ml  with  a  significant difference(P=0.001).