Hepatitis B Reactivation in Patients with Acute Myeloid Leukemia. : A Case-Control Study

Abstract

Background: HBV reactivation is a major complication in AML patients receiving chemotherapy.
Objective: To evaluate HBV reactivation among HBsAg-positive AML patients and how HBV infection may be re activated by the effect of chemical drugs used in treatment of hematological abnormalities Methods: Case-control study including 25 AML patients and 25 AML patients HBV negative in single center study all of them was over 18 years. Results: Eight patients (32%) developed HBV reactivation and two deaths occurred while the others of case group remain nonactivated patients .
Conclusions: HBV reactivation remains a significant clinical challenge requiring  routine  screening  and  prophylaxis  specially  in  patients  on hematological abnormality .