Predictive value of serum uric acid and coronary artery calcium scoring for ischemic heart disease

Abstract

Low-dose computer tomography (CT) scanning of the heart is a non- invasive method that provides quantitative information of the calcification of the coronary vessels. High serum uric acid (SUA) level is known to be associated with various cardiovascular (CVD) risk factors and diseases such as hypertension, diabetes mellitus, and metabolic syndrome. Recently, some researches show that higher SUA levels are linked with an increased risk of hospitalizations related to chronic kidney diseases, mortality, and also CVDs .Its role as a risk factor for cardiovascular disease is studied extensively;  however,  whether  the  association  is  independent  of conventional risk factors is controversial. The study aimed to value of CT coronary artery calcium scoring in hyperuricemic patients as a predictive risk for development of ischemic heart disease. The current study was conducted on at Ibn-Alnafees teaching Hospital, from 1st of November 2023 to the end of May 2024. The study included 168 patients, 118 male patients and 50 female patients. All patients underwent a proper history taking  and  thorough  physical  examination  and  were  sent  for  the biochemical investigations. Electrocardiogram done for all patients. Echo study  done  for  those  Electrocardiography  was  not  giving  exclusive diagnosis. CT coronary artery calcium score and CT Angiography were done for all patient diagnosed as coronary artery disease. The study for coronary  artery  disease  patients  shows  There  is  a  strong  correlation between hyperuricemic patients, coronary artery calcium and lipid profile in patient with ischemic heart disease and there was also a significant increase  of  Calcium  score  which  is  approved  by  non-contrast  CT Angiography and then confirmed this strong correlation by contrast CT Angiography that shows the luminal arterial defects in diabetic patients group.