Anti-Mullerian Hormone in Women with Recurrent Miscarriage

Abstract

In  recent   years,   accumilated   data   indicate   that   "anti-mullerian   hormonme (AMH)"  reflects  the  number  of  follicles  that  have  made  the  transition   from  the primordial   pool   into  the  growing   follicle  pool,   and  that   is  not  controlled   by gonadotropins.     ~Ovarian  reserve   tests  would  be  considered   incomplete   without AMH  measurement.  The  study hypothesis  aimed  to answer  a question:  Is there  a correlation  between  recurrent  unexplained   pregnancy  loss  and diminished  ovarian
reserve   as reflected  by serum level of AMH?  sixty three non-pregnant  female  (34
females with history of unexplained three or more pregnancy losses within the last 5 years and 29 multiparas females without history of recurrent miscarriage as control). twenty six (41%) of the whole women included in the study had normal AMH while 22 (35%) of them had low and just 15 (24%) recorded high levels. Sixteen (44%) of women >35 year had low AMH compared to just 6 (22%) in women <35 year which was significantly different. Only 6 (17%) of those >35 year old had high AMH level. AMH level between women in cases and control showing that overall women with recurrent miscarriage had statistically significant lower AMH than in women in the control group (50%) and (17%) respectively. Although young women <35 years old in cases had lower AMH level (27%) compared to those in control (8%) but the difference was statistically not significant. In women > 35 years old AMH levels were significantly lower in cases (68%) than in control (23.5%), even after adjusting for age .Four women (35.5%) in the control group had high AMH level while only one of women in cases group recorded such level.