Relation of maternal 25 (OH) D Concentration and preterm labour

Abstract

Background:  
WHO reported that about 15 million neonates are born preterm, with about million deaths occurring during infancy PTB infants who survive frequently suffer from chronic pulmonary diseases and  learning  deficits,  causing  heavy  burdens  for  society  and family. This study aimed at finding the relation between preterm labour and maternal (25(OH) D blood level.  
Subject and Methods 
A prospective cohort study, conducted in obstetric department in Salah Al-Deen general hospital from 31  Jan to the 11  July 2021. 
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A convenient sample of 154 pregnant women in the 2nd trimester were taken and followed up for assessment of pregnancy outcome. Inclusion criteria include all pregnant women aged 18-45 years, and  planned  delivery  at  Salah  Al-Deen  general  Hospital.  Data collection   done   through:   standardized   questionnaire.   Blood samples were collected from the mothers on 13-24 week and ≥32 week and followed to report the prevalence of preterm delivery. Results:  
                 Deficient vitamin D3 found among 40 (27%) of the total pregnant women, insufficient level found among 110 (73%) of the women while none of the pregnant women had sufficient vitamin D3 at 32 week of gestation. Vitamin D3 deficiency found among 3 (12%) of the preterm labour and 2(1.2%) of the full term labour group, while insufficient vitamin D3 found among 21 (84%) of the preterm labour and 108 (83.7 %) full-term labour in a statistically significant relation. The correlation of the vitamin D3 level at 13- 24 week of gestation and gestational age show significant linear (r= 0.426). The correlation of the vitamin D3 level at 24 - 32 week of gestation and gestational age show significant linear (r= 0.449). Conclusions: 
             Vitamin D3 deficiency found significantly among women of the preterm labour than the full term labour group.