The Effect of Vitamin D deficiency on Central Obesity and Fatty Liver in Female within Reproductive Age

Abstract

Background: The complications of central obesity and the rapidly increasing burden have become important health issues. There is inverse relationship between the status of vitamin D (VD) and obesity .VD deficiency is a risk factor for the development of Nonalcoholic fatty liver disease (NAFLD), also VD deficiency was associated with atherosclerotic cardiovascular disease. The aim of the study is to assess the level of VD in young female with central obesity, assess the parameters of central obesity and its association with VD deficiency.

Methods: This study was based on a case control with sample of (80) young females' aged from14-45 years. The females in study were single or married but not pregnant. Females divided in to 2 groups' forty having central obesity and forty did not have central obesity, the parameters measured are VD level by i-chroma-II, BMI (kg/m²) and waist-hip ratio. Fatty liver diagnosed by liver ultrasound .The differences in parameter measured between two groups were analyzed.

Results: Eighty females divided into two groups: 40 with central obesity and 40 without central obesity, VD (10.6) was significantly low among female with central obesity. The BMI (30.0) and WHR (0.95) among the central obesity group were significantly high. The incidence of fatty liver within central obesity group was significant. The correlation of VD with BMI, WHR and fatty liver were weak and indirect.

Conclusion: There is a positive correlation between VD deficiency and the pathogenesis of central obesity in young female, the study found the low VD levels associated significantly with developing NAFLD. So it is important to monitor VD levels, decrease the risk of obesity and screen for NAFLD.