The correlation between Apo B lipoprotein and lipid profile in Patients with Non-Alcoholic Fatty Liver Disease

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent etiology of chronic liver disease globally. NAFLD is a spectrum of disease defined by hepatic steatosis in the absence of identifiable secondary causes of hepatic fat buildup, such as excessive alcohol intake. NAFLD encompasses a spectrum from the relatively benign non-alcoholic fatty liver (NAFL) to the more severe non-alcoholic steatohepatitis (NASH). NAFLD may advance to fibrosis and cirrhosis. The liver plays an important role in lipid metabolism, including importing Free FAs (FFAs) and manufacturing, storing, and exporting lipids, and the dysregulation of these processes in the liver can lead to the development of NAFLD.

Objective: determine the correlation between Apo B and lipid profile in Patients with NAFLD

Patients and Methods: A study was conducted at Azadi Teaching Hospital from   1 June of 2024 to   15 June   2025.   The   study   involved   90 participants, 60 with NAFLD and 30 healthy subjects. The study used a spectrophotometer to determine various parameters, High-density lipoprotein(HDL), Triglyceride(TG), and cholesterol. ELISA washer and reader also used for measurement of Apo B.

Result: Age of patients ranging from 20 to 65 years. Serum level of Apo B lipoprotein and lipid profile were measured and compared to control group, Apo B was significantly higher in patients with NAFLD.However lipid (TRI, CHOL, VLDL, LDL) also were measured and they were significantly higher in patient group than control group, while HDL level was lower in patients than controls.

Conclusion: Positive correlation between Apo B and HDL while negative correlation with other lipid (tri,chol,VLDL,LDL)