Evaluation of The Level of Interleukin 6, IL-6, Superoxide Dismutase and glutathione peroxidase in patients With Lupus systemic Lupus Erythematosus

Abstract

Backgrounds: Prone to flare-ups, systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that varies in severity and progression. In SLE, both innate and adaptive immune responses are implicated. Gene-environment interactions cause a variety of immunologic alterations that lead to persistent immune responses to autologous nucleic acids. Morbidity and mortality are increased when autoantibodies or immune-complex depositions cause tissue damage to the kidneys, heart, arteries, central nervous system, skin, lungs, muscles, and joints.

Materials and Methods: The current study, which was conducted in the Baghdad Governorate between December 2024 and the end of March 2025, involved 90 sample patients between the ages of 10 and >60 who were severely affected by systemic lupus erythematous and were being closely monitored by a specialist physician in terms of treatment and clinical condition observation. However, 30 individuals without SLE were included in the control group. The levels of Interleukin-6 (IL-6) and Superoxide Dismutase (SOD), glutathione peroxidase (GPX), and Source (Elk. Biotechnology-China) were measured in the lab for both groups using ELISA.

Results: The present study showed that the level of IL-6 serum were highly significant (p< 0.001). As well as, there is a significant reduction in serum level of Superoxide Dismutase and Glutathione peroxidase.

Conclusion: There was a strong positive correlation between Superoxide Dismutase, Glutathione peroxidase and Interleukin 6 Level.