Estimation of some immunological biomarkers in aborted women infected with human cytomegalovirus (HCMV) in Salah Al-deen province

Abstract

Background Human Cytomegalovirus (CMV) is the most common cause of congenital malformation resulting from viral intrauterine infection in developed countries. Congenital HCMV infection causes severe morbidity and mortality in newborns and is the infectious cause of deafness, vision loss, and mental retardation and neurodevelopmental abnormalities in children.The aim of this study was to estimate of some immunological parameters in aborted women infected with Human Cytomegalovirus (HCMV) in Salah Al-deen province. Pateints & Methods:This study was carried out on 128 pregnant women with abortion at 15-45 years who attended Tikrit teaching hospital in Salah Al-deen province. Five ml of blood were drawn from each pregnant woman for separation of the sera. The ELISA test was used for estimating the levels of   CMV-IgM and CMV-IgG antibodies in patient's serum.
The Results The present study revealed that 21 out of 128 (16.40%) aborted women had antibodies against CMV (either IgM or IgG), while 83.59% of women were without known cause of abortion. The aborted pregnant women with CMV infection was 21 (16.40%) out of 128 pregnant women with abortion, while, it was 107(83.59%) aborted women had other causes of abortion, meantime the major of pregnant women with abortion were positive for CMV-IgG which reached 71.42%, whereas the percentage of CMV-IgM positive was 28.57 %. The most infected age groups with CMV infection was 25 – 34 years old, which represented 12 (57.14%), case. The most infected patients from rural area was 71.42%, while in urban was 28.57%. The most pregnant women with CMV infection were had previous abortions within first trimester (less than 12 weeks of gestational age) was 55.5% case. The conclusion of this study was the seropositive of pregnant women with CMV high at 25-34 years age from rural area especially at first trimester.