Evaluation the Sensitivity of Copeptin and Some Biochemical Parameters for Atherosclerosis

Abstract

Background: This study assesses diagnostic sensitivity and specificity of a variety of biochemical markers, including Copeptin, Spexin, Galectin-9, Netrin-1, and conventional lipid profiles in early atherosclerosis detection. Materials  and  Methods:A case-control  study  was  conducted  on  90 subjects which included atherosclerosis patients and healthy controls. Blood samples were tested for lipids and biomarker levels. 
Results:Results  showed  significant  differences  in  lipids  such  as cholesterol, LDL, and HDL in comparison between two groups coinciding with  traditional  atherosclerotic  risk  factors.  Among  new  biomarkers, Copeptin  demonstrated  high  accuracy.  The  others  showed  variable sensitivity and specificity.
Conclusion: Develop an understanding about the significance of these biomarkers  in  regard  to  their  potential  roles  in  atherosclerosis  early diagnosis  and  management,  in  order  to  help  develop  more  effective protocols for screening and treatment.