The Role of IL8 and IL17A in thalassemia patients infected with toxoplasmosis in Diyala province

Abstract

Background: Toxoplasma gondii is an obligate intracellular protozoan parasite, a unicellular eukaryote that resides within host cells and impacts around one-third of the global population, particularly patients that are immunocompromised.
Aim: To evaluate the importance of IL8 and IL17A in serum of the thalassemia patients infected with T.gondii .
Patients and methods : This study conducted on 50 thalassemia patients  and 25 sample collected  from healthy  people as a control group . During the period from May 2024 to December  2024 .
Results: A significant difference (P≤0.01)  has been found in value of IL8 and IL17A in thalassemia patients infected by toxoplasmosis compared with control group. We have been recorded increased  the mean level of both IL8 and IL17A  in thalassemia patients with toxoplasmosis compared with control group.
Conclusions: The serum mean levels of pro-inflammatory cytokines such as IL8 and IL17A  appear to be elevated  in thalassemia patients with serological evidence of T.gondii infection.