Evaluation of the Effect of Reishi Mushroom "Ganoderma lucidum" on Antioxidant in Rats

Abstract

There are many incidents that lead to oxidative stress resulting from reactive oxygen species. Many plants including fruits, vegetables and fungi are recognized as sources of natural antioxidants that can protect against oxidative stress such as mushrooms like, Ganoderma lucidum including many  compounds  can protect against oxidative stress. In this study we aimed to investigate the antioxidant effects of Ganoderma lucidum  (Red  Reishi  Mushroom)  on  liver  histologically  by  light microscopy,  measurement  of    some  biochemical  parameters (cholesterol, tricholesterol , HDL,VLDL, LDL and glutathione). We use 20 male rats weighing around 200-250g , which were divided into 4 groups.  The  first  group  as  a  control  group  1  didn't  receive  any medication and gained free access to food and water. The second group received hydrogen peroxide H2O2. The third group received vitamin C + H2O2. The fourth group received Ganoderma lucidum + H2O2 for 30 days.    After experiment,  we  analyze  the  results  (histopathological sections  of  liver  and  detection  of  biochemical  parameters  such  as cholesterol,  tricholesterol  ,HDL,VLDL.LDL  and  glutathione)  to reveal the effects of Ganoderma lucidum and antioxidant compared with the other groups with  duration of exposure.