Lipid Profile in Prediction of Pre-Eclamptic Pregnant Women in Tikrit-Iraq

Abstract

This study is a prospective case-control study involving 50 pre-eclamptic and 50 healthy pregnant women at the Tikrit Teaching Hospital from November 2022 to June 2023. The two groups were controlled for age, parity, and gestational age. Fasting serum total cholesterol (TC), triglyceride (Tg), high-density lipoprotein-cholesterol (HDL), low-density lipoprotein-cholesterol (LDL), and very low-density lipoprotein (VLDL) were assayed using standard methods. An interview was carried out with those patients using a questionnaire form that included their demographic characteristics (age, body weight, height, blood pressure, edema, and maternal body mass index). A proper obstetric, abdominal, and medical examination, ultrasonography, and laboratory investigations were done. The mean ± SD of the TC (230.54±40.3), Tg (191.14±47.3), LDL (125.6±26.3), and VLDL (42.44 ±13.4) were higher in pre-eclampsia (PE) than the control group (165.06± 24.02), (153.3±31.6), (105.3±13.7), and (35.3±8.3), respectively. The mean ± SD of the HDL (37.58±7.6) was lower among the PE group than the control group (42.18±8.3). The mean ± SD of the TC (257.5±31.02), Tg (209.1±40.41), HDL (37.1±5.8), LDL (141.7±23.6), and VLDL (44.5±9.3) were higher among the severe PE group than the mild PE group (195.1±17.05), (174.2±24.7), (39.35±5.4), (123.2±20.3), and (39.3±7.6), respectively. As well as the control group (165.06± 24.02), (153.3±31.6), (42.18±8.3), (105.3±13.7), and (35.3±8.3), respectively. Serum lipid levels were significantly raised among pre-eclamptic pregnant women when compared to healthy pregnant women. The raised serum lipid level was higher among cases with severe PE than those with mild PE.