Levels of Interleukin-6 in Colorectal Carcinoma Patients in Relation to Metastasis degree

Abstract

Background: Colorectal cancer is the third most common form of cancer and  the  second  leading  cause  of  death  among  cancers  in  the  Western World. Adenocarcinoma represents 98% of colorectal cancer. In Iraq, It is the 7th most common malignant tumor according to the commonest ten cancers  by  site  in  2005.  the  7th  commonest  in  male  ,  while  the  4th commonest in female
Materials and Methods: This cross-sectional study was done in Kirkuk city from the beginning of March  2017 to the end of April 2018. The study include 50 patient (27 male and 23 female) with different degree of CRC  (from  new  diagnosis  to  metastasis),  their  age  were  27-77  years,  these patients were attended to Kirkuk oncology center evaluating the role of interleukin-6 in progression and prognosis of colorectal carcinoma. This study also included 40 healthy blood donors as control group. Five ml blood was collected from each patient and control enrolled in the study for determination of serum IL-6 level. 
Results:  The  study  found  that  highest  rate  (56%)  of  CRC  patient  of admitted to Kirkuk oncology center were above 50 years old and 20% were below 30 years, Table 1. The study showed that 60% of CRC patient were in the first grade of the cancer (without metastasis), 30% in the grade 2 and only 20% were in the grade 3 of progression of the cancer, Table 1. In this study, IL- 6 was significantly elevated in CRC patient comparing with healthy control (P<0.05), Table 3 show mean and standard deviation of IL- 6 which recorded 33.79±6.22 pg/ml on CRC patients versus 6.6±0.91 pg/ml in  the  control  group.  Interleukin- 6    showed  significant  elevated  level (P<0.05) in CRC patients who in the grade 3 (i.e: who with advanced stage of metastasis) (37.19±7.12 pg/ml), followed by CRC patients in grade 2 (28.24±5.59  pg/ml)  and  the  lowest  mean  of  IL- 6  was  found  in  CRC patients who didn’t suffer from metastasis (20.27±3.21 pg/ml.)
It was concluded that the there was a significant relation of interleukin elevation with promote colorectal cancer.